![]() Treating Moderate or Severe Hypercalcemiaįor many people with myeloma, drinking extra fluids is not enough to treat hypercalcemia. This can help flush extra calcium out of the body. If calcium levels aren’t high enough to cause symptoms, doctors may recommend drinking extra fluids. Other times, people have severe hypercalcemia that may be life-threatening if not treated. Some cases of hypercalcemia don’t cause any symptoms. Treatment for Hypercalcemiaĭoctors use different treatments for hypercalcemia depending on how severe it is. They often can’t perform this job as well in people with multiple myeloma. Usually, the kidneys remove extra calcium from the blood. ![]() Myeloma cells make high levels of abnormal proteins, which damage the kidneys. Kidney problems may also cause abnormal calcium levels in people with multiple myeloma. As the bone breaks down, it releases calcium into the blood. ![]() People with multiple myeloma have bone that is weakened and dissolves faster than new bone is produced. However, multiple myeloma activates osteoclasts - cells that break down bone. Normally, the body balances the breakdown of old bone with the formation of new bone. Researchers believe that people with multiple myeloma have high calcium levels because of bone disease. High calcium levels are often a sign that treatment isn’t working or that the myeloma has relapsed (come back after being treated). Those without hypercalcemia lived for 57 months. In one study, people with hypercalcemia lived an average of 40 months after being diagnosed with myeloma. People with multiple myeloma who are hypercalcemic have a worse prognosis than those with normal calcium levels. If a person with one of these conditions develops high calcium levels, it is a sign that their condition has turned into multiple myeloma. People with MGUS and SMM do not have CRAB symptoms, including hypercalcemia. Bone lesions (damage, tumors, or abnormalities in the bone).Anemia (low levels of red blood cells) or low platelet counts (cells that help clot the blood).Signs of organ damage caused by myeloma are called CRAB symptoms, with CRAB standing for: Certain signs of organ damage signal to a doctor that a person has full-blown multiple myeloma rather than MGUS or SMM. All of these disorders cause increased levels of plasma cells or abnormal antibodies. There are three stages of plasma-cell disorders: monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), and multiple myeloma. Calcium levels help doctors diagnose myeloma and affect a person’s prognosis (outlook). It is important to check calcium levels in people with plasma cell disorders. Multiple myeloma is one of several conditions that affects the plasma cells (a type of white blood cell). A simple blood test can show whether any of these symptoms are caused by abnormal calcium levels. If you notice any of these symptoms, talk to your doctor. Others with more severe hypercalcemia can experience: ![]() Many people with high calcium levels don’t have any symptoms. Additionally, high calcium levels can develop because of medications, dehydration, or certain endocrine disorders. Other cancers also lead to this condition. Multiple myeloma is not the only condition that causes hypercalcemia. Doctors measure calcium levels with a blood test.
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